TY  - JOUR
T1  - HEpatic blood flow and metabolism
AU  - MacDonald A, Marble AE, Perkins JG
Y1  - 1979/05/01
N1  - 10.1001/archsurg.1979.01370290066014
JO  - Archives of Surgery
SP  - 616
EP  - 622
VL  - 114
IS  - 5
N2  - • The relationship between liver blood flow and hepatic metabolism remains unclear. An animal model as well as a methodology that permits simultaneous assessment of both of these functions are proposed. Several fractions of inspired oxygen were used to produce arterial oxygen levels commonly seen in clinical practice; these ranged from hyperoxemia to established hypoxemia. Over this range there were no considerable changes in transhepatic blood flow, but there were considerable changes in hepatic metabolism as shown by measurements of the hepatic parenchymal pH, transhepatic oxygen consumption, and lactic acid use. Of these, the parenchymal pH seems to be the most sensitive indicator of metabolic events.(Arch Surg 114:616-622, 1979)
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.1979.01370290066014
UR  - http://dx.doi.org/10.1001/archsurg.1979.01370290066014
ER  -