TY  - JOUR
T1  - BIochemical adaptation of venous patches placed in the carotid circulation
AU  - Govostis DM, Bandyk DF, Bergamini TM, Towne JB
Y1  - 1989/04/01
N1  - 10.1001/archsurg.1989.01410040100023
JO  - Archives of Surgery
SP  - 490
EP  - 493
VL  - 124
IS  - 4
N2  - • The influence of venous patching on luminal prostacyclin (PGI2) and thromboxane A2 (TBX) production of endarterectomized arteries was studied in a canine model. Fifteen dogs underwent bilateral common carotid endarterectomies. In each dog, one artery was closed primarily and the contralateral artery was closed by vein-patch angioplasty. At six and 12 weeks after operation, luminal prostanoid production from the venous patch, adjacent endarterectomized artery, and control artery and vein was measured by radioimmunoassay for 6-keto-prostaglandin F1α and thromboxane B2. Venous patches underwent "incomplete" biochemical adaptation with decreased luminal production of PGI2 compared with control and endarterectomized arteries. Thromboxane production from venous patches was increased compared with normal vein but similar to control and endarterectomized arteries. At six weeks, PGI2 production of vein-patched arterial segments was increased compared with arteries closed primarily. These data indicate that vein-patch angioplasty favorably influences surface thrombogenicity of healing, endarterectomized arteries and support its use in reparative carotid surgery.(Arch Surg 1989;124:490-493)
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.1989.01410040100023
UR  - http://dx.doi.org/10.1001/archsurg.1989.01410040100023
ER  -