TY  - JOUR
T1  - TReatment of locally recurrent breast carcinoma
AU  - probstfeld MR, O'Connell TX
Y1  - 1989/10/01
N1  - 10.1001/archsurg.1989.01410100025005
JO  - Archives of Surgery
SP  - 1127
EP  - 1130
VL  - 124
IS  - 10
N2  - • Treatment of locally recurrent breast carcinoma remains a significant problem. The records of 106 patients with local chest wall recurrence were reviewed. Fifty-five percent eventually developed metastatic disease, while 45% remained free of systemic disease. Size of primary tumor (>2 cm), number of recurrences (multiple), and disease-free interval from primary surgery (<2 years) were all highly significant for the development of metastatic disease. Negative estrogen receptors also predicted bad prognosis. Both irradiation and surgery used alone had high local failure rates of 83% and 62%, respectively, but combination radiation-surgery treatment failed only in 25%. Combination radiation-surgery treatment should be considered in patients with local recurrence, but further prospective trials with more patients will be needed to prove its effectiveness. Patients with unfavorable prognostic factors should be considered for adjuvant chemotherapy.(Arch Surg. 1989;124:1127-1130)
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.1989.01410100025005
UR  - http://dx.doi.org/10.1001/archsurg.1989.01410100025005
ER  -