TY  - JOUR
T1  - GLutamine-supplemented total parenteral nutrition improves gut immune function
AU  - Burke DJ, Alverdy JC, Aoys E, Moss GS
Y1  - 1989/12/01
N1  - 10.1001/archsurg.1989.01410120042009
JO  - Archives of Surgery
SP  - 1396
EP  - 1399
VL  - 124
IS  - 12
N2  - • Glutamine has been demonstrated to be an important source of fuel for the gut. The purpose of this study was to evaluate the effect of glutamine-supplemented hyperalimentation on gut immune function. Thirty-six female Fischer rats were randomized into three groups: group 1 (chow) was fed rat chow and water ad libitum, group 2 (total parenteral nutrition) received a standard hyperalimentation formula, and group 3 (total parenteral nutrition–glutamine) received a hyperalimentation solution that contained 2% glutamine. Animals were maintained on their respective diets for 2 weeks and then killed. Mesenteric lymph nodes were harvested for culture, bile was assayed for secretory IgA, and bowel was excised to assay bacterial adherence. Results indicated that glutamine-supplemented total parenteral nutrition protects against bacterial translocation from the gut seen with standard formulas. This effect may be mediated by the secretory IgA immune system.(Arch Surg. 1989;124:1396-1399)
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.1989.01410120042009
UR  - http://dx.doi.org/10.1001/archsurg.1989.01410120042009
ER  -