TY  - JOUR
T1  - EFfect of thyroid gland volume in preoperative detection of suspected malignant thyroid nodules in a multinodular goiter—invited critique
AU  - Clark OH
Y1  - 2008/06/16
N1  - 10.1001/archsurg.143.6.563
JO  - Archives of Surgery
SP  - 563
EP  - 563
VL  - 143
IS  - 6
N2  - 
Overall, 100 thyroid cancers were identified in these 69 patients, 41 in the dominant nodule and 59 elsewhere in the thyroid gland. Smaller thyroid glands (< 38 mL) had a 48-fold increased rate of malignancy, whereas large nodules (> 7 mm) also had a significantly increased rate of being thyroid cancer. This overall cancer rate of 18.9% seems a little higher than expected. This may be due to the use of fine-needle aspiration cytology. The increased rate of thyroid cancer may also be caused by some selection or referral bias. The authors' findings seem to make sense, since patients with larger goiters have a reason other than cancer for an enlarged thyroid gland, including growth factors, such as epidermal growth factor, thyroid-stimulating hormone, and insulin like growth factor. When I examine a patient with a thyroid nodule, I try to palpate the rest of the thyroid gland as well as the pyramidal lobe. When I palpate the pyramidal lobe, I know that there is a general stimulus to the thyroid gland so that a malignant neoplasm is less likely.

SN  - 0004-0010
M3  - doi: 10.1001/archsurg.143.6.563
UR  - http://dx.doi.org/10.1001/archsurg.143.6.563
ER  -