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 Showing 61-80 of 116 Articles

Perhaps the most reliable expectation of obesity treatment is variability. We see vast heterogeneity in treatment response to bariatric surgery, pharmacotherapy, behavioral therapy, medically and self-directed weight loss, and other modalities, each ranging from near-miraculous benefits to null, or even negative, effects. For example, weight loss from bariatric ...

JAMA Surgery Clinical Challenge 
Corrado Pedrazzani, MD; Marco Vitali, MD; Alfredo Guglielmi, MD

A woman in her 70s presents with an asymptomatic mass of the gastric fundus. What is your diagnosis?

Research Letter 
Jun Tashiro, MD, MPH; David J. Gerth, MD; Seth R. Thaller, MD, DMD

This study identifies the factors associated with flap-related complications and increased resource utilization in patients with pressure ulcers.

Research Letter 
Amelia W. Maiga, MD, MPH; Stephen A. Deppen, PhD; Rhonda Pinkerman, ACNP; Eric L. Grogan, MD, MPH

This study examines pulmonary resection as a diagnostic and therapeutic strategy for patients with known or suspected lung cancer.

Comment & Response 
Maria Ida Maiorino, MD, PhD; Giuseppe Bellastella, MD, PhD; Katherine Esposito, MD, PhD

To the Editor We read with interest the article by Courcoulas et al1 comparing the remission rate of type 2 diabetes mellitus (T2DM) following surgical treatment and the remission rate of T2DM following nonsurgical treatment among obese individuals after 3 years of follow-up. They concluded that among ...

Comment & Response 
Anita P. Courcoulas, MD, MPH; John M. Jakicic, PhD

In Reply We, too, were puzzled by the lack of remission of type 2 diabetes (T2DM) in the lifestyle intervention–alone group despite a standardized program delivered by experienced interventionists that resulted in comparable weight loss and similar magnitudes of improvement in lipids and blood pressure levels as in ...

Comment & Response 
Peyman Benharash, MD; William Toppen, BA

To the Editor In our previously published Invited Commentary,1 Mr Toppen’s degree was inadvertently reported as “MD.” In fact, Mr Toppen is a fourth-year medical student, and his degree should have been reported as “BA.” We apologize to the editor, the editorial board, and the readers for ...

Correction  FREE

In the Invited Commentary titled “Bundles of Care for Patients With Ruptured Abdominal Aortic Aneurysms: Is Endovascular Repair the Solution?” published online August 5, 2015, in JAMA Surgery,1 the degree of the second author, William Toppen, was inadvertently reported as “MD.” Mr Toppen is a fourth-year ...

Original Investigation 
Michaela Kollisch-Singule, MD; Sumeet Jain, MD, MBA; Penny Andrews, RN; Bradford J. Smith, PhD; Katharine L. Hamlington-Smith, PhD; Shreyas Roy, MD; David DiStefano, BS; Emily Nuss, BS; Josh Satalin, BS; Qinghe Meng, MD; William Marx, DO; Jason H. T. Bates, PhD; Louis A. Gatto, PhD; Gary F. Nieman, BA; Nader M. Habashi, MD

Importance  Ventilator-induced lung injury may arise from heterogeneous lung microanatomy, whereby some alveoli remain collapsed throughout the breath cycle while their more compliant or surfactant-replete neighbors become overdistended, and this is called dynamic alveolar heterogeneity.

Objective  To determine how dynamic alveolar heterogeneity is influenced by ...

Original Investigation 
Junaid A. Bhatti, MBBS, MSc, PhD; Avery B. Nathens, MD, PhD, FRCSC; Deva Thiruchelvam, MSc; Teodor Grantcharov, MD, PhD; Benjamin I. Goldstein, MD, PhD, FRCPC; Donald A. Redelmeier, MD, MSHSR, FRCPC

Importance  Self-harm behaviors, including suicidal ideation and past suicide attempts, are frequent in bariatric surgery candidates. It is unclear, however, whether these behaviors are mitigated or aggravated by surgery.

Objective  To compare the risk of self-harm behaviors before and after bariatric surgery.

Design, Setting, and Participants...

Invited Commentary: Bariatric Surgery; Amir A. Ghaferi, MD, MS; Carol Lindsay-Westphal, PhD
Original Investigation 
Robert H. Hollis, MD; Brandon A. Singletary, MPH; James T. McMurtrie, BS; Laura A. Graham, MPH; Joshua S. Richman, MD, PhD; Carla N. Holcomb, MD; Kamal M. Itani, MD; Thomas M. Maddox, MD, MSc; Mary T. Hawn, MD, MPH
Includes: Supplemental Content

Importance  Although liberal blood transfusion thresholds have not been beneficial following noncardiac surgery, it is unclear whether higher thresholds are appropriate for patients who develop postoperative myocardial infarction (MI).

Objective  To evaluate the association between postoperative blood transfusion and mortality in patients with coronary artery disease ...

Invited Commentary: Optimal Transfusion Trigger in Surgical Patients With Coronary Artery Disease; Steven M. Frank, MD; Aslam Ejaz, MD, MPH; Timothy M. Pawlik, MD, MPH, PhD
Invited Commentary 
Amir A. Ghaferi, MD, MS; Carol Lindsay-Westphal, PhD

Bariatric surgery is the most effective treatment of morbid obesity with a proven survival benefit.1,2 To view bariatric surgery as simply a weight loss procedure is misguided and can lead to inappropriate expectations and potentially dangerous consequences.

Invited Commentary 
Steven M. Frank, MD; Aslam Ejaz, MD, MPH; Timothy M. Pawlik, MD, MPH, PhD

Among patients with known coronary artery disease (CAD), the ideal transfusion trigger based on nadir hemoglobin is still unclear. Three of the largest randomized clinical trials on transfusion triggers and perioperative outcomes were performed among cardiac patients undergoing cardiac surgery,13 a clinical scenario that is ...

Surgical Innovation 
Zaynab Jawad, MSc, MRCS; Fang Xie, PhD; Long R. Jiao, MD, FRCS

This Surgical Innovation discusses the applications arising from nanotechnology for therapeutic and diagnostic use in cancer.

Research Letter 
SreyRam Kuy, MD, MHS; Peter Jenkins, MD; Ramon A. L. Romero, MD; Navdeep Samra, MD; SreyReath Kuy, DPM

This study attempts to determine the changes in the incidence and outcomes of Clostridium difficile–associated megacolon over a 10-year period.

Research Letter 
Laura A. Graham, MPH; Robert H. Hollis, MD; Joshua S. Richman, MD, PhD; Mary T. Hawn, MD, MPH

This study hypothesizes that surgery cancellations are more frequent in the first 6 months following the placement of a drug-eluting stent and that a higher proportion of early cancellations are associated with acute myocardial infarction or death.

To the Editor Whereas classic teaching highlights reduced infection risk, fewer hospitalizations, and lower total costs associated with hemodialysis (HD) that is initiated via arteriovenous fistula (AVF) vs hemodialysis catheter (HC), and whereas the National Kidney Foundation–Kidney Disease Outcomes Quality Initiative1 first published practice guidelines regarding permanent ...

Original Investigation 
Jan Peter Yska, PharmD; Eric N. van Roon, PharmD, PhD; Anthonius de Boer, MD, PhD; Hubert G. M. Leufkens, PharmD, PhD; Bob Wilffert, PharmD, PhD; Loek J. M. de Heide, MD; Frank de Vries, PharmD, PhD; Arief Lalmohamed, PharmD, PhD
Includes: Supplemental Content

Importance  To our knowledge, an observational study on the remission of type 2 diabetes mellitus (T2DM) after different types of bariatric surgery based on data from general practice has not been carried out.

Objective  To assess the effect of different types of bariatric surgery in patients ...

Original Investigation 
Christopher R. Connelly, MD; Amy Laird, PhD; Jeffrey S. Barton, MD; Peter E. Fischer, MD; Sanjay Krishnaswami, MD; Martin A. Schreiber, MD; David H. Zonies, MD; Jennifer M. Watters, MD
Includes: Supplemental Content

Importance  Although rare, the incidence of venous thromboembolism (VTE) in pediatric trauma patients is increasing, and the consequences of VTE in children are significant. Studies have demonstrated increasing VTE risk in older pediatric trauma patients and improved VTE rates with institutional interventions. While national evidence-based guidelines for ...

Invited Commentary: Pediatric Venous Thromboembolism—Like Adult Clots, Only Smaller; Matthew J. Martin, MD
Original Investigation 
Russ S. Kotwal, MD, MPH; Jeffrey T. Howard, PhD; Jean A. Orman, ScD, MPH; Bruce W. Tarpey, BS; Jeffrey A. Bailey, MD; Howard R. Champion, FRCS; Robert L. Mabry, MD; John B. Holcomb, MD; Kirby R. Gross, MD
Includes: Supplemental Content

Importance  The term golden hour was coined to encourage urgency of trauma care. In 2009, Secretary of Defense Robert M. Gates mandated prehospital helicopter transport of critically injured combat casualties in 60 minutes or less.

Objectives  To compare morbidity and mortality outcomes for casualties before vs ...

Invited Commentary: The Power of Advanced Capability and Informed Policy; Todd E. Rasmussen, MD

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