http://archsurg.jamanetwork.com/ en-us Mon, 24 Dec 2012 00:00:00 GMT Tue, 01 Jan 2013 00:50:31 GMT Silverchair editor@archsurg.jamanetwork.com webmaster@archsurg.jamanetwork.com http://archsurg.jamanetwork.com/article.aspx?articleID=1216544 Thu, 01 Nov 2012 00:00:00 GMT Ryan JA. <span class="paragraphSection">The use of intraoperative PTH testing to assure that no abnormally functioning parathyroids remain in the patient after removal of 1 parathyroid adenoma has slipped into widespread clinical use. In my opinion, this is unfortunate since the outcomes of this strategy have not been subjected to randomized clinical trials. Observational studies from the active, experienced, and world-renowned endocrine surgeons at the University of California, San Francisco have demonstrated less than 50% predictive success rate in patients with double parathyroid adenomas, a 13% false-negative rate with single parathyroid adenomas, a negative influence of hemolysis on the reliability of IOPTH measurement, and now the suggestion that race and BMI may impact PTH kinetics.</span> 147 11 1041 1041 10.1001/archsurg.2012.1496 http://archsurg.jamanetwork.com/article.aspx?articleID=1216544