Showing 1 – 20 of 743
Relevance | Newest | Oldest |
  • Withholding Proton Pump Inhibitors to Prevent Recurrent Clostridium difficile : Time for a Randomized Trial

    Abstract Full Text
    free access
    JAMA Intern Med. 2017; 177(6):791-791. doi: 10.1001/jamainternmed.2017.0233
  • Association of Proton Pump Inhibitors and Capecitabine Efficacy in Advanced Gastroesophageal Cancer: Secondary Analysis of the TRIO-013/LOGiC Randomized Clinical Trial

    Abstract Full Text
    JAMA Oncol. 2017; 3(6):767-773. doi: 10.1001/jamaoncol.2016.3358

    This secondary analysis of the TRIO-013 phase 3 randomized clinical trial attempts to determine if gastric acid suppressants such as proton pump inhibitors may impair capecitabine efficacy.

  • Association of Gastric Acid Suppression With Recurrent Clostridium difficile Infection: A Systematic Review and Meta-analysis

    Abstract Full Text
    JAMA Intern Med. 2017; 177(6):784-791. doi: 10.1001/jamainternmed.2017.0212

    This meta-analysis examines the association between recurrent Clostridium difficile infection and use of gastric acid suppressant medications.

  • JAMA Oncology June 1, 2017

    Figure 2: Overall Survival

    Kaplan-Meier curves show overall survival betweens patients treated with or without proton pump inhibitors (PPIs) and (A) capecitabine and oxaliplatin (CapeOx) alone or (B) CapeOx with lapatinib.
  • JAMA Oncology June 1, 2017

    Figure 1: Progression-Free Survival

    Kaplan-Meier curves show progression-free survival betweens patients treated with or without proton pump inhibitors (PPIs) and (A) capecitabine and oxaliplatin (CapeOx) alone or (B) CapeOx with lapatinib.
  • JAMA Psychiatry June 1, 2017

    Figure 5: Exploratory Analyses

    A, Activation in the ventromedial prefrontal cortex (vmPFC) during early fear conditioning is associated with vmPFC activation during extinction recall. This association was only significant in healthy controls and failed to reach significance in the anxiety group. B, Shown are significant associations between brain regions demonstrating significant psychophysiological interaction (PPI) between-group differences during extinction recall and skin conductance response (SCR) during extinction recall. Expression of extinction recall is the computation of SCR to the first 4 trials of extinguished conditioned stimuli minus SCR to the first 4 trials of nonextinguished conditioned stimuli.aP < .05.
  • Drug-Drug Interactions With Oral Antineoplastic Agents

    Abstract Full Text
    JAMA Oncol. 2017; 3(6):736-738. doi: 10.1001/jamaoncol.2016.3323

    This Viewpoint addresses the increasing incidence of drug-drug interactions with personalized cancer treatment drugs.

  • A Year in Review

    Abstract Full Text
    free access
    JAMA Neurol. 2017; 74(4):383-383. doi: 10.1001/jamaneurol.2016.6004
  • Patterns of Prescription Drug Use Before and After Fragility Fracture

    Abstract Full Text
    JAMA Intern Med. 2016; 176(10):1531-1538. doi: 10.1001/jamainternmed.2016.4814

    This pharmacoepidemiology study uses Medicare Part D data to describe changes in use of prescription drugs associated with an increase in fracture risk before and after fragility fractures.

  • National Practice Patterns of Antireflux Medication for Chronic Rhinosinusitis

    Abstract Full Text
    JAMA Otolaryngol Head Neck Surg. 2016; 142(7):627-633. doi: 10.1001/jamaoto.2016.0937

    This cross-sectional analysis uses data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey to determine whether chronic rhinosinusitis is associated with administration of antireflux medications.

  • Sticky Palms Following Use of Proton-Pump Inhibitors

    Abstract Full Text
    free access
    JAMA Dermatol. 2016; 152(6):722-723. doi: 10.1001/jamadermatol.2016.0094

    This case report describes 2 patients with sticky palms as an adverse effect of proton-pump inhibitors.

  • Estimation of Potential Savings Through Therapeutic Substitution

    Abstract Full Text
    free access has multimedia
    JAMA Intern Med. 2016; 176(6):769-775. doi: 10.1001/jamainternmed.2016.1704

    This cross-sectional study estimates potential savings through therapeutic substitution in terms of both overall and out-of-pocket expenditures of branded drugs when a generic in the same class with the same indication was available.

  • Effect of Detecting and Isolating Clostridium difficile Carriers at Hospital Admission on the Incidence of C difficile Infections: A Quasi-Experimental Controlled Study

    Abstract Full Text
    free access
    JAMA Intern Med. 2016; 176(6):796-804. doi: 10.1001/jamainternmed.2016.0177

    This quasi-experimental controlled study investigates the effect of detecting and isolating Clostridium difficile asymptomatic carriers at hospital admission on the incidence of health care–associated C difficile infection in a Canadian acute care facility.

  • Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes

    Abstract Full Text
    free access
    JAMA. 2016; 315(19):2104-2112. doi: 10.1001/jama.2016.5657

    This study characterizes the histologic features of esophageal inflammation in patients with acute gastroesophageal reflux disease during and after discontinuation of proton pump inhibitor treatment.

  • JAMA May 17, 2016

    Figure 1: Study Design

    LA indicates Los Angeles; GERD-HRQL, Gastroesophageal Reflux Disease Health-Related Quality of Life; PPI, proton pump inhibitor.
  • JAMA May 17, 2016

    Figure 3: Representative Images of the Distal Esophagus From a Single Patient at Baseline and at 1 Week and 2 Weeks After Discontinuation of PPI Therapy

    LA indicates Los Angeles; PPI, proton pump inhibitor. At baseline, HD-WLE showed an irregular tongue of columnar mucosa (Barrett esophagus) in the 12 o’clock position, but no esophagitis. At day 9, HD-WLE showed long linear mucosal breaks (4 and 6 o’clock positions) extending up the esophagus from the gastroesophageal junction (LA grade B esophagitis). At day 16, HD-WLE showed long mucosal breaks continuous between the tops of mucosal folds (LA grade C esophagitis). CLE revealed fluorescein within bright intraepithelial capillaries (yellow arrowheads), with fluorescein that leaked from blood vessels into intercellular spaces surrounding individual cells, creating a reticular appearance characteristic of squamous epithelium. CLE measurements revealed widened intercellular spaces with increased intercellular fluorescein at days 9 and 16. In the photomicrographs at day 9 and 16, black arrowheads indicate some of the numerous intraepithelial lymphocytes. Note the prominent lymphocytosis, basal cell hyperplasia, and papillary elongation at 2 weeks after discontinuation of PPI therapy. All photomicrographs are H&E stains, original magnification ×20. All images were modified in Photoshop to remove patient identification data, and to enhance clarity. Any adjustments in contrast, color balance, brightness or sharpness were applied to the entire image.
  • JAMA Internal Medicine May 9, 2016

    Author Video Interviews: Potential Savings Through Therapeutic Substitution

    is video
  • JAMA May 9, 2016

    JAMA Report Video: Potential Savings Through Therapeutic Substitution

    is video
  • Inappropriate Prescription of Proton Pump Inhibitors in the Setting of Steroid Use: A Teachable Moment

    Abstract Full Text
    JAMA Intern Med. 2016; 176(5):594-595. doi: 10.1001/jamainternmed.2016.0603

    This case of a woman in her 60s presenting with ear fullness and asymetric hearing loss is a reminder to carefully consider indications for treatment using proton pump inhibitors in the setting of steroid use.

  • Do Proton Pump Inhibitors Increase the Risk of Dementia?

    Abstract Full Text
    JAMA Neurol. 2016; 73(4):379-381. doi: 10.1001/jamaneurol.2015.4931