This secondary analysis of the TRIO-013 phase 3 randomized clinical trial attempts to determine if gastric acid suppressants such as proton pump inhibitors may impair capecitabine efficacy.
This Viewpoint addresses the increasing incidence of drug-drug interactions with personalized cancer treatment drugs.
This pharmacoepidemiology study uses Medicare Part D data to describe changes in use of prescription drugs associated with an increase in fracture risk before and after fragility fractures.
This cross-sectional analysis uses data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey to determine whether chronic rhinosinusitis is associated with administration of antireflux medications.
This case report describes 2 patients with sticky palms as an adverse effect of proton-pump inhibitors.
This cross-sectional study estimates potential savings through therapeutic substitution in terms of both overall and out-of-pocket expenditures of branded drugs when a generic in the same class with the same indication was available.
This quasi-experimental controlled study investigates the effect of detecting and isolating Clostridium difficile asymptomatic carriers at hospital admission on the incidence of health care–associated C difficile infection in a Canadian acute care facility.
This study characterizes the histologic features of esophageal inflammation in patients with acute gastroesophageal reflux disease during and after discontinuation of proton pump inhibitor treatment.
This case of a woman in her 60s presenting with ear fullness and asymetric hearing loss is a reminder to carefully consider indications for treatment using proton pump inhibitors in the setting of steroid use.
This cohort study examines the association between the use of proton pump inhibitors and the risk of incident dementia in an elderly German population.
In a nationally representative sample of older adults, this study characterizes changes in the prevalence of medication use and quantifies the frequency and types of potential major drug-drug interactions.
This population-based cohort study quantifies the association between proton pump inhibitor use and incident chronic kidney disease among participants in the Atherosclerosis Risk in Communities study.
This article reviews the pathophysiology, clinical presentation, diagnostic evaluation, and treatment of gastroesophageal reflux disease.
This review article found that laparoscopic antireflux surgery is a very effective and long-lasting treatment for gastroesophageal reflux disease.
After adjustment for other independent predictors of recurrence, this retrospective cohort study finds that patients with continuous proton pump inhibitor exposure remained at elevated risk of Clostridium difficile infection recurrence.
Sachar et al compare intermittent proton pump inhibitor therapy with the currently recommended intravenous bolus plus continuous-infusion regimen for reduction of ulcer rebleeding.