Batchu et al determine whether generating melanoma antigen family A, 3 (MAGE-A3), a tumor-specific cancer-testis antigen, as a fusion protein with cell-penetrating domain will enhance the cytosolic bioavailability of MAGE-A3. Berger provides discussion in a related Invited Commentary.
This review examines the published evidence on the use of biological mesh materials and the US Food and Drug Administration approval history for these devices.
This study evaluates the association between preoperative use of narcotics and postoperative outcomes in patients with Crohn disease.
This analysis of data from an ongoing prospective trial determines that laparoscopic repair of paraesophageal hernia results in excellent long-term quality of life (QOL). See also the invited commentary by Oleynikov.
This study describes the broad spectrum of nonvascular surgery cases that require intraoperative vascular surgery assistance.
This study assesses whether the MGMT protein expression in patients with late-stage gastric cancer is associated with prognosis or the need for fluorouracil-based adjuvant chemotherapy.
This cohort study uses the National Cancer Database to examine the factors associated with underestimation of invasive cancer in patients with a clinical diagnosis of non–high-grade DCIS that would preclude active surveillance.
This population-based cohort study evaluates the association of primary tumor site with mortality among patients receiving systemic chemotherapy and biologic therapy for metastatic colorectal cancer.
This cohort study uses data from the Department of Defense Military Health System Data Repository to describe patterns of opioid pain medication prescriptions after common surgical procedures and determine the appropriateness of the prescription as indicated by the rate of refills.
This cohort study examines satisfaction and quality-of life in women who undergo fat grafting for breast reconstruction after mastectomy.
This study evaluates whether private vehicle prehospital transport confers a survival advantage vs ground emergency medical services transport following penetrating injuries in urban trauma systems.
This study describes the oncologic safety of nipple-sparing mastectomy and provides evidence-based data regarding preservation of the nipple-areolar complex during a risk-reducing mastectomy in a population with BRCA mutations.
This single-center study of patients undergoing vascular surgery determines the association between kidney disease and long-term postoperative cardiovascular-specific mortality.
This review summarizes the field of oncologic anthropology—a transdisciplinary field of research on the racial/ethnic variations in cancer—and discusses breast cancer in white American, African American, and African women.
This retrospective review shows that most patients with stage IV colorectal cancer had undergone primary tumor resection but, beginning in 2001, a trend toward fewer resections was seen. Despite the decreasing resection rate, patient survival rates improved.
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