This clinical trial analyzes the feasibility and clinical benefit of intraoperative near infrared fluorescence sentinel lymph node excision (SLNE) compared with standard technetium Tc 99m–guided SLNE in 80 patients with malignant melanoma on the trunk or extremities.
This study reports that patients with node-positive esophageal adenocarcinoma benefit significantly from neoadjuvant chemoradiation, while patients with node-negative tumors do not gain significant overall survival as compared with surgery alone.
Kadera and colleagues aimed to perform a detailed survival analysis of their institution’s experience with patients with locally advanced/borderline resectable pancreatic ductal adenocarcinoma who were downstaged and underwent surgical resection and (2) identify prognostic biomarkers that may help guide a decision for the use of adjuvant therapy in this patient subgroup. L. Andrew DiFronzo, MD, provided an invited commentary.
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